Kenneth Connors nsIn hmolscience, Kenneth Connors (1932-) is an American pharmacologist, a pioneer of pharmaceutical thermodynamics, noted for 2002 footnote on the analogies between balancing components of energy and entropy in physical systems, quantified by free energy, and balancing components of security and liberty (freedom) in social systems, quantified by politics.

Thermodynamics | Security vs liberty
In 2002, Connors, in his Thermodynamics of Pharmaceutical Systems, footnotes a politics type explanation of free energy, i.e. a type of political thermodynamics, as a compromise between security and freedom (or liberty), as follows: [1]

“It is not too fanciful to draw an analogy with a political science setting, in which each society must choose its own compromise position between the extremes of maximum security (the energy component) and maximum liberty (the entropy component).”

In 2010, Connors, together with co-author Italian-born American pharmaceutical chemist Sandro Mecozzi (Ѻ), in their second edition, restated the above footnote, albeit in a little more organized fashion, with the footnote bottom page, versus end of chapter (2002), showing a free energy diagram concordantly; the newer presentation, with the footnote inserted, reads as follows: [3]
Figure 3.1 (Connors, 2010)
Connor’s figure 3.1 captioned as “free energy of a reacting chemical system, showing how the direction of the reaction depends on the initial state of the system”, amid his free energy and political science discussions. [3]

“The essential characteristic of the Gibbs free energy function is its combination of both energy and entropy components in a form that reveals how these two thermodynamic concepts complete to generate a compromise that determines the position of equilibrium in a chemical process. It is not too fanciful to draw an analogy with a political science setting, in which each society must choose its own compromise position between the extremes of maximum security (the energy component) and maximum liberty (the entropy component). A more negative ΔH favors spontaneous reaction, and a more positive ΔS favors spontaneous reaction, in both instances making ΔG more negative.”

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This comparison is strikingly similar to American thermodynamicist Frederick Rossini's 1971 "Chemical Thermodynamics in the Real World" address. Connors, to note, does cite Rossini’s 1950 Chemical Thermodynamics textbook twice, though he does not seem to be aware of his 1971 Priestley Medal address (nor of the Rossini debate).

Education
Connors completed his undergraduate degree in 1954 in pharmacy at the University of Connecticut. He completed his MS (1957) and PhD (1959) in pharmacy, focus pharmaceutical analysis, at the University of Wisconsin, Madison, under the direction of American pharmacologist Takeru Higuchi, a graduate of the Lewis school of thermodynamics, known as the “father of physical pharmacy”, pioneer of the application of physical chemistry theory to drug design, delivery, and analysis. [2] In 1962, Connor became a professor of pharmacy at the University of Wisconsin at Madison, remaining there over the next forty plus years.

References
1. Connors, Kenneth A. (2002). Thermodynamics of Pharmaceutical Systems: an Introduction to Students of Pharmacy (ch. 3: The Free Energy, pgs. 30-41, esp. 41). John Wiley and Sons.
2. (a) Anon. (2002). “2002 UW Honorary Citation Report: Kenneth A. Connors”. School of Pharmacy, University of Wisconson-Madison.
(b) Hersey, Mark D. (1987). “It’s all in the Delivery: Hat’s off to Higuchi”, Oct. 17, KUHistory.com.
3. Connors, Kenneth A. and Mecozzi, Sandro. (2010). Thermodynamics of Pharmaceutical Systems (pgs. 95-96). Wiley.

Further reading
● Connors, Kenneth A. (1990). Chemical Kinetics: the Study of Reaction Rates in Solution. Wile.
● Connors, Kenneth A., Amidon, Gordon L, and Stella, Valentino J. (1986). Chemical Stability of Pharmaceuticals: Handbook for Pharmacists. Wiley.
● Connors, Kenneth A. (1987). Binding Constants: the Measure of Molecular Complex Stability. Wiley.

External links
Connors, Kenneth A. (Kenneth Antonio) (1932-) – WorldCat Identities.
Kenneth A. Connors (faculty) – University of Wisconsin, Madison.

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