In chemistry, thermosynthesis refers to the synthesis of products from reactants or components in reactions or processes that are driven by heat.

The term “thermosynthesis”, referring to synthesis (formation or building of more complex structures from simpler elements or compounds) by heat, has been around since the 1940s.

Muller’s biothermosynthesis
A recent proponent of the term, in the context of biosynthesis, has been Danish physical chemist and biophysicist Anthonie Muller, who wrote his first paper on thermosynthesis in 1983, and has since been an active researcher and promoter of the term. [1] Muller defines thermosynthesis as biological heat engines working on thermal cycling. [2] In the context of the origin of life, Muller defines thermosynthesis as a theoretical biological mechanism for free energy gain from thermal cycling, tentatively slated as the energy source for the origin of life. [3]

1. (a) Anthonie Muller (background) – (AWJMuller).
(b) Muller, Anthonie W.J. (1985). "Thermosynthesis by biomembranes: energy gain from cyclic temperature changes". Journal of Theoretical Biology 115: 319-321.
2. Muller, Anthonie W.J. (2009). “Emergence of Animals from Heat Engines - Part 1: Before the Snowball Earths” (abstract), Entropy, 11(3): 463-512.
3. Muller, Anthonie W. J. (2005). “A Search for Thermosynthesis: Starvation Survival in Thermally Cycled Bacteria.” Department of Geology, University of Washington.

External links
Thermosynthesis – Wikipedia.
Thermosynthesis (homepage) – (AWJMuller).
Re: Paper on Thermosynthesis (notes) –

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