In chemistry, biochemistry, related to "organic chemistry", is a obsolete portmanteau, i.e. bio- (defunct) + -chemistry (not defunct), meant to signify the chemical study of powered CHNOPS+ systems, i.e. "biological", defunct colloquial speak, processes, structures, or systems in.

The term “bio” traces to Greek Euripides (c.420BC); the term “biology” to German Theodore Roose (1797).

In 1877, Felix Seyler (1825-1895) (Ѻ), German physician, pathologist, and physiological chemist, introduced the term “biochemistry” to be the name of a new department of chemistry he was aiming to found:

“The term ‘biochemistry’ [biochemie] is to be taken as short for ‘physiological chemistry’, and institutes dedicated to this field of study, taken as a new independent discipline with the physiological sciences, needs to be established.”
— Felix Seyler (1877), forward [paraphrase quote] to first issue (Ѻ) of Journal of Physiological Chemistry [5]

In 1896, John Mandel, in his Handbook for the Bio-Chemical Laboratory (Ѻ), was using term “bio-chemical” in respect to the methods used to obtain chemicals such as: glycogen (C6H10O5), i.e. multibranched polysaccharide of glucose, aka the white powder derived from the liver of a large rabbit, that serves as a form of energy storage in animals and fungi, lactose (C12H22O11), i.e. milk sugar, maltose (C12H22O11), i.e. potato starch, etc. The key-terms: life, alive, and living, however, are not used in Mandel’s book.

In 1903, Carl Neuberg, a German chemist , supposedly, was using the term “biochemistry” as a classification term for the subjects he had been working on, namely: solubility and transport in cells, the chemistry of carbohydrates, photochemistry, investigating and classifying different types of fermentation, and the chemistry of amino acids and enzymes. [1]

What is Biochemistry (1973)
Swedish physiological-biochemist Gosta Ehrensvard's 1973 Living Matter: What is Life? What is Biochemistry?, showing DNA on the cover, wherein he questions the functionability of the terms “biochemistry” and “living matter” as a working scientific labels. [4]
Difficulties on term
In the 20th century, chemists began to point out that the term “biology”, or the study of life, was not something recognized by the science of “chemistry”, the study of atoms and their properties, a subject that does not utilized, recognize, understand, and or quantify physically the notions of “life” and “death”. This was explicitly pointed out in 1939 by English physiologist Charles Sherrington: [2]

Chemistry does not know the word life.”

In 1966, English molecular geneticist Francis Crick put forward the following suggestion, amid his neo-vitalism debates: [3]

“Let us abandon the word ‘alive’.”

These issues become acute when one goes searching for the so-called "origin of life" at which point the molecular entity/biological entity divide, such as in the case of the cell (e.g. cell-as-molecule) or virus (e.g. virus molecule), becomes a striking problem in need of immediate solution and resolution, particularly when chemical thermodynamic analysis is used as the tool of dissection.

Swedish physiological-biochemist Gosta Ehrensvard, following the proposal of his 1960 “life precedes organisms” living puddle theory, in his We and They: Molecules and Life in the Cosmos (1971) and Living Matter: What is Life? What is Biochemistry? (1973), seems to have begun to lay question to the functionability of the terms “biochemistry” and “living matter” as a working scientific labels. [4]

Terminology upgrade
In the wake of the post 2009 "defunct theory of life" perspective, in circa 2012, to remedy this ongoing terminology malady, American electrochemical engineer Libb Thims began to initiate “life terminology upgrade” clarification measures in both Hmolpedia articles and submitted Journal of Human Thermodynamics articles. The term “biochemistry”, in all its usages, has subsequently been redacted as follows:

bio-chemistry (biochemistry) → powered chnops-chemistry (chnopschemistry).


The following are related quotes:

“The prefix bio is essential; in living things we are dealing with bio-physical, bio-chemical, bio-mechanical phenomena. Life has a bio-physicochemico-mechanical basis.”
— Henry Osborn (1925), “The Origin of Species as Revealed by Vertebrate Paleontology” [1]

1. (a) Trehan, Keshav. (1990). Biochemistry (pg. 20). New Age International.
(b) Carl Neuberg – Wikipedia.
2. Sherrington, Charles. (1940). Man on His Nature (pg. #). CUP Archive.
3. Crick, Francis. (1966). Of Molecules and Men. University of Washington Press.
4. (a) Ehrensvard, Gosta. (1971). We and They: Molecules and Life in the Cosmos (Vi och de: molekyler och liv i kosmos) (editors: Gosta Ehrensvard and Jan Stenflo). Publisher.
(b) Ehrensvard, Gosta. (1973). Living Matter: What is Life? What is Biochemistry? (Levande materia: vad är liv? vad är biokemi?). Aldus.
5. (a) Teich, Makulas. (1970). “The Historical Foundations of Modern Biochemistry”, in: The Chemistry of Life (editor: Joseph Needham) (pgs. 171-91, quote, pgs. 190-91). Cambridge.
(b) Kremer, Richard. (1984). The Thermodynamics of Life and Experimental Physiology, 1770-1880 (pg. 23). Publisher.

External links
Biochemistry – Wikipedia.

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